Articles
This collection of articles represents some of the leading science in resuscitation and post-arrest care. Questions regarding these articles should be directed to the authors. If you feel we have missed an important article, please send us an email at ttmTraining@pennmedicine.upenn.edu.
Post-arrest TTM RCTs
Hypothermia versus Normothermia After Out-of-Hospital Cardiac Arrest
June 17, 2021• The New England Journal of Medicine
Dankiewicz et al. (TTM2 Trial Investigators)
In an open-label randomized controlled trial with blinded assessment of outcomes, 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause were randomized to undergo targeted hypothermia at 33°C, followed by controlled rewarming, or targeted normothermia with early treatment of fever (body temperature, ≥37.8°C).
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Targeted temperature management for cardiac arrest with nonshockable rhythm.
December 12, 2019 • The New England Journal of Medicine
Lascarrou JB et al.
Randomized controlled trial of hypothermia at 33 °C vs. normothermia (37 °C) in comatose patients with coma who had been admitted to the intensive care unit (ICU) after resuscitation from cardiac arrest with nonshockable rhythm.
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Nordberg P et al.
International, multicenter, randomized controlled trial of patients who experienced out-of-hospital cardiac arrest. Randomized to receive intra-nasal evaporative intra-arrest cooling versus standard care. Both groups received systemic therapeutic hypothermia to 32 °C to 34 °C.
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Randomized controlled trial of 24h vs. 48h of hypothermia to 33 °C in adults with out-of-hospital cardiac arrest.
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Targeted temperature management at 33°C versus 36°C after cardiac arrest.
December 5, 2013 • The New England Journal of Medicine
Randomized controlled trial comparing two different target temperatures of hypothermia: 33 °C and 36 °C. Enrolled patients with out-of-hospital cardiac arrest of presumed cardiac cause.
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Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia
February 21, 2002 • New England Journal of Medicine
Small randomized controlled trial of patients with out-of-hospital cardiac arrest with ventricular fibrillation as the presenting rhythm. Randomized to hypothermia to 33 °C vs. no targeted temperature management.
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Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest
February 21, 2002 • New England Journal of Medicine
Hypothermia After Cardiac Arrest Study Group
Multicenter randomized controlled trial of patients who had been resuscitated after cardiac arrest due to ventricular fibrillation. Randomized to hypothermia to 32-34 °C over a period of 24 hours vs. standard treatment with normothermia.
Targeted Temperature Management
Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry.
Post-arrest Coronary Angiography
Neurologic Assessment and Prognostication
Postresuscitation Care and Prognostication
September 15, 2021 • Current Opinion in Critical Care
Nolan JP & Abella BS
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January, 2019 • Science Direct: Resuscitation
Kim JH et al.
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Continuous Amplitude-Integrated Electroencephalographic Monitoring Is a Useful Prognostic Tool for Hypothermia-Treated Cardiac Arrest Patients.
August 12, 2015 • AHA Journals: Circulation
Oh SH et al.
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Time to awakening and neurologic outcome in therapeutic hypothermia-treated cardiac arrest patients.
December 5, 2013 • Science Direct: Resuscitation
Grossestreuer AV et al.
Expert Commentary
PODCAST: EMCrit 307 – TTM2 Episode Retort with Ben Abella & Joe Tonna
September 23, 2021 by Scott Weingart, MD FCCM
